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The Federal Reserve Bank of St. Louis, often referred to as the St. Louis Fed, is one of the 12 regional banks that make up the United States Federal Reserve System. It is responsible for the Eighth Federal Reserve District, which includes the states of Arkansas, Illinois, Indiana, Kentucky, Mississippi, Missouri, and Tennessee, as well as portions of eastern Kansas and southern Illinois.

The St. Louis Fed, like other regional banks, participates in the formulation and implementation of monetary policy in the United States. It contributes to the Federal Open Market Committee (FOMC) meetings, where key decisions regarding interest rates and other monetary policy tools are made.